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Article

Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor 1.

The Journal of biological chemistry - 20 Aug 2004

Pop Marius, Aktories Klaus, Schmidt Gudula

Abstract excerpt

The cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli activates members of the Rho family by deamidation of glutamine 61/63. Because this amino acid is crucial for GTP hydrolysis, deamidation of glutamine 61/63 results in constitutively active Rho proteins. Recently, it was shown that the level of CNF1-activated Rac is rapidly diminished in CNF1-treated cells by proteolytic degradation. Here, we studied...

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Identifiers

PMID: 15143066
DOI: 10.1074/jbc.M404346200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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