Characterization of the effector-specifying domain of Rac involved in NADPH oxidase activation.

doi:10.1074/jbc.270.34.19868

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Article

Characterization of the effector-specifying domain of Rac involved in NADPH oxidase activation.

The Journal of biological chemistry - 25 Aug 1995

Kwong C H, Adams A G, Leto T L

Abstract excerpt

Production of microbicidal oxidants by phagocytic leukocytes requires activation of a latent NADPH oxidase by the coordinated assembly of a membrane-associated flavocytochrome b558, with three cytosolic components, p47phox, p67phox, and the low molecular weight GTP-binding protein Rac. Rac1 and R...

Topics

Amino Acid Sequence
Animals
Binding Sites
Cell Cycle Proteins
Enzyme Activation
GTP-Binding Proteins
Humans
In Vitro Techniques
Molecular Sequence Data
Mutation
NADH, NADPH Oxidoreductases
NADPH Oxidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutrophils

Oxidation-Reduction

Recombinant Fusion Proteins

Sequence Homology, Amino Acid

Structure-Activity Relationship

cdc42 GTP-Binding Protein

Source

Open in PubMed

Identifiers

PMID: 7649999
DOI: 10.1074/jbc.270.34.19868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7649999-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Characterization of the effector-specifying domain of Rac involved in NADPH oxidase activation.PMID 7649999Read ↗

The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1.Semantic proximity Read ↗

Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism.Semantic proximity Read ↗

MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity.Semantic proximity Read ↗

Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.Semantic proximity Read ↗

The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization.Semantic proximity Read ↗

Plant rac proteins induce superoxide production in mammalian cells.Semantic proximity Read ↗

p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox.Semantic proximity Read ↗

The molecular basis of Rac-GTP action-promoting binding of p67phox to Nox2 by disengaging the β hairpin from downstream residues.Semantic proximity Read ↗

The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2Semantic proximity Read ↗

Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif.Semantic proximity Read ↗

Fc receptor-mediated phagocytosis requires CDC42 and Rac1.Semantic proximity Read ↗

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.Semantic proximity Read ↗

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