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Article

Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin.

Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007

Iliev Asparouh I, Djannatian Jasmin Roya, Nau Roland, Mitchell Timothy J, Wouters Fred S

Abstract excerpt

The Streptococcus pneumoniae toxin pneumolysin belongs to the group of cholesterol-dependent cytolysins. It produces rapid cell lysis at higher concentrations or apoptosis at lower concentrations. In cell membranes, it forms prepores and pores. Here, we show that sublytic concentrations of pneumo...

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Identifiers

PMID: 17301241
DOI: 10.1073/pnas.0608213104
PMCID: PMC1815278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17301241-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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