Article
A deletion polymorphism in glutathione-S-transferase mu (GSTM1) and/or theta (GSTT1) is associated with an increased risk of toxicity after autologous blood and marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jun 2010
Hahn Theresa, Zhelnova Eugenia, Sucheston Lara, Demidova Irina, Savchenko Valery, Battiwalla Minoo, Smiley Shannon L, Ambrosone Christine B, McCarthy Philip L
Abstract excerpt
Toxicity after blood and marrow transplantation (BMT) has interindividual variability that may be explained by common genetic polymorphisms in critical pathways. The glutathione-S-transferase (GST) isoenzymes detoxify the reactive oxygen species generated by chemotherapy agents and radiation. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.