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Article

Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer

1 May 2004

Abstract excerpt

Pancreas cancer is the fourth leading cause of cancer-related death in adults in the United States. New molecular targets for diagnosis and therapy of this disease are desperately needed. In this study, we report on the mitotic serine-threonine kinase polo-like kinase 1 (Plk1) in pancreatic cancer. Plk1 mRNA was found to be overexpressed in 9 of 10 tested pancreatic cancer cell lines and in 4 of 4 tested human...

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PMID: 15141022
DOI: 10.1158/1535-7163.641.3.5

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