Article
Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation.
Genes, chromosomes & cancer - 1 Jul 2004
Kittiniyom Kanokwan, Mastronardi Michelle, Roemer Martha, Wells Wendy A, Greenberg E Robert, Titus-Ernstoff Linda, Newsham Irene F
Abstract excerpt
DAL-1/4.1B (EPB41L3)is a member of the protein 4.1 superfamily, which encompasses structural proteins that play important roles in membrane processes via interactions with actin, spectrin, and the cytoplasmic domains of integral membrane proteins. DAL-1/4.1B localizes within chromosomal region 18p11.3, which is affected by loss of heterozygosity (LOH) in various adult tumors. Reintroduction of this protein into...
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