Article
Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene.
Genomics - 15 Jul 1999
Wong A K, Chen Y, Lian L, Ha P C, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian S V, Teng D H
Abstract excerpt
Human CDC14A is a dual-specificity phosphatase that shares sequence similarity with the recently identified tumor suppressor, MMAC1/PTEN/TEP1. By radiation hybrid mapping, we localized CDC14A to chromosome band 1p21, a region that has been shown to exhibit loss of heterozygosity in highly differentiated breast carcinoma and malignant mesothelioma. We have mapped the exon-intron structure of CDC14A gene and found...
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