Article
Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer.
Molecular and cellular biology - 1 Nov 2005
Yi Chunling, McCarty Joseph H, Troutman Scott A, Eckman Matthew S, Bronson Roderick T, Kissil Joseph L
Abstract excerpt
The band 4.1 proteins are cytoskeletal proteins, harboring a conserved FERM domain highly homologous to the N-terminal FERM domain of ezrin, radixin, moesin, and merlin. Recently, a truncated form of the 4.1B protein, termed Dal-1, was identified in a screen as down regulated in adenocarcinoma of the lung and was mapped to chromosome 18p11.3, which is lost in 38% of primary non-small cell lung carcinoma tumors....
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