Article
The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study.
International journal of molecular medicine - 1 Jun 2004
Strandhagen Elisabeth, Zetterberg Henrik, Aires Nibia, Palmér Mona, Rymo Lars, Blennow Kaj, Landaas Sverre, Thelle Dag S
Abstract excerpt
Some methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are associated with hyperhomocysteinemia. Trials have shown a plasma homocysteine raising effect of coffee. We determined the effect of a daily intake of 600 ml coffee and a supplementation of 200 microg folic acid or placebo on plasma homocysteine (tHcy) with respect to the MTHFR C677T and A1298C polymorphisms. One hundred and twenty healthy,...
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