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Article

Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome

11 May 2004

Abstract excerpt

Down syndrome (DS) is the most common chromosomally caused form of mental retardation and is caused by trisomy of chromosome 21. The over-expression of genes located on the trisomic region has been assumed to be responsible for the phenotypic abnormalities of DS, but this hypothesis has not been confirmed fully and the very existence of gene dosage effects has been called into question. We have therefore...

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PMID: 15138197
DOI: 10.1093/hmg/ddh154

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