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Article

Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post‐natal development

17 Jan 2006

Abstract excerpt

To understand the aetiology and the phenotypic severity of Down syndrome, we searched for transcriptional signatures in a substructure of the brain (cerebellum) during post-natal development in a segmental trisomy 16 model, the Ts1Cje mouse. The goal of this study was to investigate the effects of trisomy on changes in gene expression across development time. The primary gene-dosage effect on triplicated genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16635258
DOI: 10.1111/j.1471-4159.2005.03624.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post‐natal developmentPMID 16635258Read ↗

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