Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

Abstract excerpt

BACKGROUND: Down syndrome is a chromosomal disorder caused by the presence of three copies of chromosome 21. The mechanisms by which this aneuploidy produces the complex and variable phenotype observed in people with Down syndrome are still under discussion. Recent studies have demonstrated an increased transcript level of the three-copy genes with some dosage compensation or amplification for a subset of them....

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