Article
Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility.
Circulation - 3 Aug 2010
Vergeer Menno, Boekholdt S Matthijs, Sandhu Manjinder S, Ricketts Sally L, Wareham Nicholas J, Brown Morris J, de Faire Ulf, Leander Karin, Gigante Bruna, Kavousi Maryam, Hofman Albert, Uitterlinden Andre G, van Duijn Cornelia M, Witteman Jacqueline C M, Jukema J Wouter, Schadt Eric E, van der Schoot Ellen, Kastelein John J P, Khaw Kay-Tee, Dullaart Robin P F, van Tol Arie, Trip Mieke D, Dallinga-Thie Geesje M
Abstract excerpt
BACKGROUND: In contrast to clear associations between variants in genes participating in low-density lipoprotein metabolism and cardiovascular disease risk, such associations for high-density lipoprotein (HDL)-related genes are not well supported by recent large studies. We aimed to determine whether genetic variants at the locus encoding phospholipid transfer protein (PLTP), a protein involved in HDL remodeling,...
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