Article
Long-chain adducts of trans-4-hydroxy-2-nonenal to DNA bases cause recombination, base substitutions and frameshift mutations in M13 phage.
Mutation research - 4 Jun 2004
Kowalczyk Pawel, Cieśla Jarosław M, Komisarski Marek, Kuśmierek Jarosław T, Tudek Barbara
Abstract excerpt
Oxidative stress enhances lipid peroxidation (LPO) implicated in the promotion and progression of carcinogenesis. One of the major LPO products is trans-4-hydroxy-2-nonenal (HNE), which was shown to react with guanosine and under peroxidizing conditions also with adenosine. We show here that all four DNA bases are targets for HNE, although displaying different reactivity: dG > dC > dA approximately equal to dT....
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