Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli.

doi:10.7150/ijbs.5.611

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Article

Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli.

International journal of biological sciences - 23 Sept 2009

Janowska Beata, Komisarski Marek, Prorok Paulina, Sokołowska Beata, Kuśmierek Jarosław, Janion Celina, Tudek Barbara

Abstract excerpt

One of the major products of lipid peroxidation is trans-4-hydroxy-2-nonenal (HNE). HNE forms highly mutagenic and genotoxic adducts to all DNA bases. Using M13 phage lacZ system, we studied the mutagenesis and repair of HNE treated phage DNA in E. coli wild-type or uvrA, recA, and mutL mutants. These studies revealed that: (i) nucleotide excision and recombination, but not mismatch repair, are engaged in repair...

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Topics

Adenosine Triphosphatases
Aldehydes
Bacteriophage M13
Base Sequence
DNA Adducts
DNA Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA, Viral

DNA-Binding Proteins

Escherichia coli

Escherichia coli Proteins

Lac Operon

Molecular Sequence Data

MutL Proteins

Mutagenesis

Mutation

Rec A Recombinases

Recombination, Genetic

Source

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Identifiers

PMID: 19834545
DOI: 10.7150/ijbs.5.611
PMCID: PMC2757579

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Source receipt: pubmed, retrieved 7 Sept 2026.

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