Mutational Spectrum and Genotoxicity of the Major Lipid Peroxidation Product, <i>trans</i>-4-Hydroxy-2-nonenal, Induced DNA Adducts in Nucleotide Excision Repair-Proficient and -Deficient Human Cells

Abstract excerpt

trans-4-Hydroxy-2-nonenal (4-HNE), a major product of lipid peroxidation, is able to interact with DNA to form 6-(1-hydroxyhexanyl)-8-hydroxy-1,N(2)-propano-2'-deoxyguanosine (4-HNE-dG) adducts, but its genotoxicity and mutagenicity remain elusive. It has been reported that 4-HNE treatment in human cells induces a high frequency of G.C to T.A mutations at the third base of codon 249 (AGG*) of the p53 gene, a...

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