Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure.

doi:10.1016/0039-128x(94)00003-u

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Article

Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure.

Steroids - 1 Jan 1995

Pascoe L, Curnow K M

Abstract excerpt

CYP11B1 (11 beta-hydroxylase) and CYP11B2 (aldosterone synthase) are steroidogenic enzymes which mediate the final step (11 beta-hydroxylation) in cortisol synthesis and the final three steps (11 beta-hydroxylation, 18-hydroxylation, and 18-oxidation) in aldosterone synthesis, respectively. The e...

Topics

Aldosterone
Blood Pressure
Crossing Over, Genetic
Genetic Diseases, Inborn
Humans
Hydrocortisone
Hyperaldosteronism
Mutation
Recombination, Genetic

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