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Article

Conditional gene silencing utilizing the <i>lac</i> repressor reveals a role of SHP‐2 in <i>cagA</i>‐positive <i>Helicobacter pylori</i> pathogenicity

1 May 2004

Abstract excerpt

RNA interference (RNAi) is a newly described biological phenomenon mediated by small interfering RNA (siRNA) that targets mRNA for degradation by cellular enzymes and has become a powerful method for studying gene functions in mammalian systems. The development of systems for inducing siRNA expression should enable examination of acute loss-of-function phenotypes in a cell of interest without the need to consider...

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Identifiers

PMID: 15132773
DOI: 10.1111/j.1349-7006.2004.tb03229.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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