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Article

Association of Ob-R gene polymorphism and insulin resistance in Japanese men.

Metabolism: clinical and experimental - 1 May 2004

Takahashi-Yasuno Akiko, Masuzaki Hiroaki, Miyawaki Takashi, Matsuoka Naoki, Ogawa Yoshihiro, Hayashi Tatsuya, Hosoda Kiminori, Yoshimasa Yasunao, Inoue Gen, Nakao Kazuwa

Abstract excerpt

Leptin and its receptors are known to play a role in glucose metabolism. We succeeded in cloning human Ob-R cDNA and revealed 7 single nucleotide polymorphisms (SNPs) (Lys109Arg, Arg223Gln, Ser343Ser, Ser492Thr, Lys656Asn, Ala976Asp, and Pro1019Pro) in the coding region of Ob-Rb. Although these 7 SNPs were not associated with an obese phenotype, several studies have reported that some of them were associated with...

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Identifiers

PMID: 15131772
DOI: 10.1016/j.metabol.2003.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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