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Article

Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population.

Frontiers in endocrinology - 1 Jan 2026

Parmar Nishant, Rathwa Nirali, Patel Roma, Pramanik Palit Sayantani, Patel Naisargi, Shetty Satyashree, Dwivedi Mitesh, Begum Rasheedunnisa, Ramachandran A V

Abstract excerpt

Background & aim: Leptin (LEP), a pro-inflammatory adipokine secreted by adipocytes acting through leptin receptor (LEPR), is critical in maintaining body weight, lipid and glucose metabolism. LEP and LEPR genetic variants are reportedly associated with type 2 diabetes (T2D). Among these, the LEPR rs1137101 A/G polymorphism has emerged as a potential determinant of metabolic risk. The current study investigates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41685250
DOI: 10.3389/fendo.2026.1693265
PMCID: PMC12890640

Genes

LEPR
LEP
TG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population.PMID 41685250Read ↗

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