Article
Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus.
European journal of endocrinology - 1 Nov 1997
Shigemoto M, Nishi S, Ogawa Y, Isse N, Matsuoka N, Tanaka T, Azuma N, Masuzaki H, Nishimura H, Yoshimasa Y, Hosoda K, Nakao K
Abstract excerpt
OBJECTIVE: Although the molecular mechanism of obesity has been poorly understood, recent studies indicate that leptin plays a critical role in regulating both food intake and body weight. Because obesity decreases the sensitivity to insulin, the human ob gene is presumed to be one of the candidate genes for non-insulin-dependent diabetes mellitus (NIDDM) associated with obesity. Although the protein coding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.