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Article

A hierarchical model of HIV-1 protease drug resistance.

Applied bioinformatics - 1 Jan 2002

Goodsell David S

Abstract excerpt

A hierarchical model of HIV-1 drug therapy may be used to evaluate new inhibitors and test new treatment strategies that address the problem of drug resistance. The model includes an atomic representation of drug-protease interaction, evaluation of viral fitness based on cleavage of polyprotein substrates during viral maturation, evolutionary modelling of drug resistance mutations in the face of selection...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15130852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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