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Article

Evolutionary analysis of HIV-1 protease inhibitors: Methods for design of inhibitors that evade resistance.

Proteins - 1 Jul 2002

Stoffler Daniel, Sanner Michel F, Morris Garrett M, Olson Arthur J, Goodsell David S

Abstract excerpt

Drug-resistant strains are rapidly selected during AIDS therapy because of the high rate of mutation in HIV. In this report, we present an evolutionary simulation method for analysis of viral mutation and its use for optimization of HIV-1 protease drugs to improve their robustness in the face of resistance mutation. We first present an analysis of the range of resistant mutants that produce viable viruses by...

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Identifiers

PMID: 12012338
DOI: 10.1002/prot.10130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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