Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromosome 10.

doi:10.4049/jimmunol.172.10.6354

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Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromosome 10.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2004

Mas Magali, Cavaillès Pierre, Colacios Céline, Subra Jean-François, Lagrange Dominique, Calise Maryline, Christen Marie-Odile, Druet Philippe, Pelletier Lucette, Gauguier Dominique, Fournié Gilbert J

Abstract excerpt

Brown Norway (BN) rats treated with aurothiopropanol-sulfonate (Atps) constitute a model of Th2-mediated immunological disorders associated with elevated IgE responses and renal IgG deposits. Using F(2) offspring between Atps-susceptible BN and Atps-resistant Lewis rats, we had previously mapped three quantitative trait loci on chromosomes 9, 10, and 20 for which BN alleles increased susceptibility to...

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PMID: 15128826
DOI: 10.4049/jimmunol.172.10.6354

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Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromosome 10.PMID 15128826Read ↗

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