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Article

Conserved 33-kb haplotype in the MHC class III region regulates chronic arthritis.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2016

Yau Anthony C Y, Tuncel Jonatan, Haag Sabrina, Norin Ulrika, Houtman Miranda, Padyukov Leonid, Holmdahl Rikard

Abstract excerpt

Genome-wide association studies have revealed many genetic loci associated with complex autoimmune diseases. In rheumatoid arthritis (RA), the MHC gene HLA-DRB1 is the strongest candidate predicting disease development. It has been suggested that other immune-regulating genes in the MHC contribute to the disease risk, but this contribution has been difficult to show because of the strong linkage disequilibrium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27303036
DOI: 10.1073/pnas.1600567113
PMCID: PMC4932949

Genes

LST1
NCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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