Article
Analysis of TNF-alpha promoter polymorphisms in the susceptibility to beryllium hypersensitivity.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG - 1 Mar 2004
Dotti Chiara, D'Apice Maria Rosaria, Rogliani Paola, Novelli Giuseppe, Saltini Cesare, Amicosante Massimo
Abstract excerpt
BACKGROUND AND AIM OF THE WORK: In susceptible individuals beryllium (Be)-exposure may cause Be-hypersensitivity (BH), leading to a spectrum of immune abnormalities ranging from the systemic responsiveness to Be to the CD4+ T-cell dominated chronic granulomatous pneumonitis known as berylliosis. Two gene markers have been previously associated with berylliosis: HLA-DP allelic variants carrying glutamate in...
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