Article
Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae.
Mutation research - 13 Sept 1999
Xiao W, Chow B L, Fontanie T, Ma L, Bacchetti S, Hryciw T, Broomfield S
Abstract excerpt
Evidence obtained from recent studies supports the existence of an error-free postreplication repair (PRR) and a mutagenesis pathway within the Saccharomyces cerevisiae RAD6 DNA repair group. The MMS2 gene is the only known yeast gene involved in error-free PRR that, when mutated, significantly increases the spontaneous mutation rate. In this study, the mutational spectrum of the mms2 mutator was determined and...
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