Article
Single-nucleotide polymorphism array coupled with multiple displacement amplification: accuracy and spatial resolution for analysis of chromosome copy numbers in few cells.
Biotechnology and applied biochemistry - 1 Jan 2000
Ling Jiawei, Deng Yu, Long Xiaolin, Liu Jianqiao, Du Hongzi, Cao Baoqiang, Xu Kangpu
Abstract excerpt
When coupled with multiple displacement amplification (MDA), microarray-based comparative genomic intensity allows detection of chromosome copy number aberrations even in single or few cells, but the actual performance of the system and their influencing factors have not been well defined. Here, using single-nucleotide polymorphism (SNP) array, we analyzed copy number profiles from DNA amplified by MDA in 1-10...
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