Article
High-resolution analysis of DNA copy number using oligonucleotide microarrays.
Genome research - 1 Feb 2004
Bignell Graham R, Huang Jing, Greshock Joel, Watt Stephen, Butler Adam, West Sofie, Grigorova Mira, Jones Keith W, Wei Wen, Stratton Michael R, Futreal P Andrew, Weber Barbara, Shapero Michael H, Wooster Richard
Abstract excerpt
Genomic copy number alterations are a feature of many human diseases including cancer. We have evaluated the effectiveness of an oligonucleotide array, originally designed to detect single-nucleotide polymorphisms, to assess DNA copy number. We first showed that fluorescent signal from the oligonucleotide array varies in proportion to both decreases and increases in copy number. Subsequently we applied the system...
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