Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTEN gene mutations in colorectal cancers displaying microsatellite instability.

Cancer letters - 28 Dec 2001

Shin K H, Park Y J, Park J G

Abstract excerpt

To determine the relationship between the mutation of the PTEN gene and genomic instability in human colorectal cancer, we screened the PTEN gene in 32 colorectal cancers (eight cell lines and 24 tissues) displaying microsatellite instability (MSI) and 32 colorectal cancers (six cell lines and 26 tissues) displaying microsatellite stability (MSS). Of 64 samples, six frameshift mutations were identified in six MSI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to Frameshift Mutation
Share to Phosphoric Monoester Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-bcl-2

Share to PTEN Phosphohydrolase

Share to Receptor, IGF Type 2

Share to Receptors, Transforming Growth Factor beta

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 11689295
DOI: 10.1016/s0304-3835(01)00691-7

Genes

PTEN
BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTEN gene mutations in colorectal cancers displaying microsatellite instability.PMID 11689295Read ↗

Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability.Semantic proximity Read ↗

Genetic alterations of sporadic colorectal cancer with microsatellite instability, especially characteristics of primary multiple colorectal cancers.Semantic proximity Read ↗

Mutations in TGFbeta-RII and BAXmediate tumor progression in the later stages of colorectal cancer with microsatellite instabilitySemantic proximity Read ↗

Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.Semantic proximity Read ↗

PTEN mutations are common in sporadic microsatellite stable colorectal cancer.Semantic proximity Read ↗

PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers.Semantic proximity Read ↗

Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.Semantic proximity Read ↗

The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer.Semantic proximity Read ↗

Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers.Semantic proximity Read ↗

Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population.Semantic proximity Read ↗

Synchronous multiple primary gastrointestinal cancer exhibits frequent microsatellite instabilitySemantic proximity Read ↗

Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.