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Selective mitochondrial DNA degradation following double-strand breaks

28 Apr 2017

Abstract excerpt

Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as reactive oxygen species, chemotherapeutic agents or ionizing radiations. MtDNA encodes for proteins involved in ATP production, and maintenance of genome integrity following DSBs is thus of crucial importance. However, the mechanisms involved in mtDNA...

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PMID: 28453550
DOI: 10.1371/journal.pone.0176795

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