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Article

Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A.

The Journal of biological chemistry - 9 Jul 2004

Leal Simone, Acosta-Serrano Alvaro, Morris James, Cross George A M

Abstract excerpt

We have engineered Trypanosoma brucei with a novel mariner transposition system that allows large populations of mutant cells to be generated and screened. As a proof of principle, we isolated and characterized two independent clones that were resistant to the cytotoxic action of concanavalin A. In both clones, the transposon had integrated into the locus encoding a homologue of human ALG12, which encodes a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15123607
DOI: 10.1074/jbc.M403479200

Genes

ALG12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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