Article
Exploiting genetic variation to discover genes involved in important disease phenotypes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015
Capewell Paul, Cooper Anneli, Clucas Caroline, Weir Willie, Vaikkinen Heli, Morrison Liam, Tait Andy, MacLeod Annette
Abstract excerpt
Elucidating the underlying genetic determinants of disease pathology is still in the early stages for many pathogenic parasites. There have, however, been a number of advances in which natural genetic diversity has been successfully utilized to untangle the often complex interactions between parasite and host. In this chapter we discuss various methods capable of exploiting this natural genetic variation to...
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