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Article

Defects in the N-linked oligosaccharide biosynthetic pathway in a Trypanosoma brucei glycosylation mutant.

Eukaryotic cell - 1 Apr 2004

Acosta-Serrano Alvaro, O'Rear Jessica, Quellhorst George, Lee Soo Hee, Hwa Kuo-Yuan, Krag Sharon S, Englund Paul T

Abstract excerpt

Concanavalin A (ConA) kills the procyclic (insect) form of Trypanosoma brucei by binding to its major surface glycoprotein, procyclin. We previously isolated a mutant cell line, ConA 1-1, that is less agglutinated and more resistant to ConA killing than are wild-type (WT) cells. Subsequently we found that the ConA resistance phenotype in this mutant is due to the fact that the procyclin either has no N-glycan or...

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Identifiers

PMID: 15075256
DOI: 10.1128/EC.3.2.255-263.2004
PMCID: PMC387663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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