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Article

Killing of Trypanosoma brucei by concanavalin A: structural basis of resistance in glycosylation mutants.

Journal of molecular biology - 8 Dec 2000

Acosta-Serrano A, Cole R N, Englund P T

Abstract excerpt

Concanavalin A (Con A) kills procyclic (insect) forms of Trypanosoma brucei by binding to N-glycans on EP-procyclin, a major surface glycosyl phosphatidylinositol (GPI)-anchored protein which is rich in Glu-Pro repeats. We have previously isolated and studied two procyclic mutants (ConA 1-1 and ConA 4-1) that are more resistant than wild-type (WT) to Con A killing. Although both mutants express the same altered...

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Source

Identifiers

PMID: 11099385
DOI: 10.1006/jmbi.2000.4246

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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