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Article

In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway.

The Journal of biological chemistry - 17 Oct 2008

Galm Ute, Wang Liyan, Wendt-Pienkowski Evelyn, Yang Runying, Liu Wen, Tao Meifeng, Coughlin Jane M, Shen Ben

Abstract excerpt

Bleomycin (BLM), an important clinically used antitumor compound, and its analogs are challenging to prepare by chemical synthesis. Genetic engineering of the biosynthetic pathway in the producer strain would provide an efficient and convenient method of generating new derivatives of this complex molecule in vivo. However, the BLM producing Streptomyces verticillus ATCC15003 has been refractory to all means of...

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Identifiers

PMID: 18697737
DOI: 10.1074/jbc.M804971200
PMCID: PMC2568937

Genes

BLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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