Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach.

Chemistry & biology - 1 Mar 2004

Otey Christopher R, Silberg Jonathan J, Voigt Christopher A, Endelman Jeffrey B, Bandara Geethani, Arnold Frances H

Abstract excerpt

Recombination generates chimeric proteins whose ability to fold depends on minimizing structural perturbations that result when portions of the sequence are inherited from different parents. These chimeric sequences can display functional properties characteristic of the parents or acquire entirely new functions. Seventeen chimeras were generated from two CYP102 members of the functionally diverse cytochrome p450...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacillus
Share to Calibration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to Mixed Function Oxygenases

Share to Peroxidase

Share to Protein Denaturation

Share to Structural Homology, Protein

Source

Identifiers

PMID: 15123260
DOI: 10.1016/j.chembiol.2004.02.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach.PMID 15123260Read ↗

Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s.Semantic proximity Read ↗

Optimized chimeragenesis; creating diverse p450 functions.Semantic proximity Read ↗

Structure-guided SCHEMA recombination of distantly related beta-lactamases.Semantic proximity Read ↗

Functionally diverging molecular quasi-species evolve by crossing two enzymes.Semantic proximity Read ↗

Extending the diversity of cytochrome P450 enzymes by DNA family shuffling.Semantic proximity Read ↗

An Evolved Orthogonal Enzyme/Cofactor Pair.Semantic proximity Read ↗

SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability.Semantic proximity Read ↗

Directed evolution of the peroxidase activity of a de novo-designed protein.Semantic proximity Read ↗

Structural flexibility and functional versatility of cytochrome P450 and rapid evolution.Semantic proximity Read ↗

De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC.Semantic proximity Read ↗

Structure-based combinatorial protein engineering (SCOPE).Semantic proximity Read ↗

Chimeric protein complexes in hybrid species generate novel phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.