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Article

Optimized chimeragenesis; creating diverse p450 functions.

Chemistry & biology - 1 Mar 2004

Bernhardt Rita

Abstract excerpt

A drawback to generating chimeric proteins by chimeragenesis, especially when the "parent" proteins share low sequence identity, is that unfolded proteins frequently result. In this issue of Chemistry & Biology, Arnold and coworkers report their use of the SCHEMA algorithm to effectively predict ideal hybrids of cytochromes p450.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15123254
DOI: 10.1016/j.chembiol.2004.03.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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