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Article

Structure-based combinatorial protein engineering (SCOPE).

Journal of molecular biology - 23 Aug 2002

O'Maille Paul E, Bakhtina Marina, Tsai Ming-Daw

Abstract excerpt

Presented here is the development a semi-rational protein engineering approach that uses information from protein structure coupled with established DNA manipulation techniques to design and create multiple crossover libraries from non-homologous genes. The utility of structure-based combinatorial protein engineering (SCOPE) was demonstrated by its application to two distantly related members of the X-family of...

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Identifiers

PMID: 12206782
DOI: 10.1016/s0022-2836(02)00675-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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