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Article

Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction.

Chemistry & biology - 1 Apr 2004

Hertweck Christian, Xiang Longkuan, Kalaitzis John A, Cheng Qian, Palzer Michelle, Moore Bradley S

Abstract excerpt

Heterologous expression and mutagenesis of the enterocin type II polyketide synthase (PKS) system suggest for the first time that the association of an extended set of proteins and substrates is needed for the effective production of the enterocin-wailupemycin polyketides. In the absence of its endogenous ketoreductase (KR) EncD in either the enterocin producer "Streptomyces maritimus" or the engineered host S....

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Identifiers

PMID: 15123240
DOI: 10.1016/j.chembiol.2004.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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