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Article

Evolutionary dynamics of modular polyketide synthases, with implications for protein design and engineering.

The Journal of antibiotics - 1 Jan 2011

Zucko Jurica, Cullum John, Hranueli Daslav, Long Paul F

Abstract excerpt

Attempts at generating novel chemistries by genetically manipulating polyketide synthases (PKSs) usually result in no detectable or poor product yield. Understanding processes that drive the evolution of PKSs might provide a solution to this problem. The synonymous-to-non-synonymous nucleotide substitution ratios across alignments of well-characterized PKS modules were examined using a sliding windows approach....

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Identifiers

PMID: 21102600
DOI: 10.1038/ja.2010.141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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