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Article

Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis.

The Journal of cell biology - 1 Sept 1992

Bowser R, Müller H, Govindan B, Novick P

Abstract excerpt

The SEC8 and SEC15 genes are essential for exocytosis in the yeast Saccharomyces cerevisiae and exhibit strong genetic interactions with SEC4, a gene of the ras superfamily. The SEC8 gene encodes a hydrophilic protein of 122 kD, while the temperature-sensitive sec8-9 allele encodes a protein prematurely truncated at 82 kD by an opal stop codon. The Sec8p sequence contains a 202 amino acid region that is 25%...

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Identifiers

PMID: 1512289
DOI: 10.1083/jcb.118.5.1041
PMCID: PMC2289594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis.PMID 1512289Read ↗

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Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p.Semantic proximity Read ↗

Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.Semantic proximity Read ↗

The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis.Semantic proximity Read ↗

The rab exchange factor Sec2p reversibly associates with the exocyst.Semantic proximity Read ↗

Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway.Semantic proximity Read ↗

The Saccharomyces cerevisiae SEC20 gene encodes a membrane glycoprotein which is sorted by the HDEL retrieval system.Semantic proximity Read ↗

SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast.Semantic proximity Read ↗

Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum.Semantic proximity Read ↗

Structural and functional dissection of a membrane glycoprotein required for vesicle budding from the endoplasmic reticulum.Semantic proximity Read ↗

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