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Article

Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.

The Journal of biological chemistry - 24 Feb 2006

Plummer Lisa J, Hildebrandt Emily R, Porter Stephen B, Rogers Victoria A, McCracken Jay, Schmidt Walter K

Abstract excerpt

The Ras converting enzyme (RCE) promotes a proteolytic activity that is required for the maturation of Ras, the yeast a-factor mating pheromone, and certain other proteins whose precursors bear a C-terminal CAAX tetrapeptide motif. Despite the physiological importance of RCE, the enzymatic mechanism of this protease remains undefined. In this study, we have evaluated the substrate specificity of RCE orthologs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16361710
DOI: 10.1074/jbc.M506284200
PMCID: PMC2937830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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