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Article

Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors.

Journal of cell science - 15 Aug 2005

Boureux Anthony, Furstoss Olivia, Simon Valérie, Roche Serge

Abstract excerpt

The cytoplasmic tyrosine kinase Abl is a Src substrate required for platelet-derived growth factor (PDGF) receptor signaling leading to Myc expression and DNA synthesis. Abl targets are, however, ill defined. Here we report that the small GTPase Rac is an important effector of its mitogenic funct...

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Share to JNK Mitogen-Activated Protein Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADH, NADPH Oxidoreductases

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Share to Proto-Oncogene Proteins c-abl

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Source

Identifiers

PMID: 16076903
DOI: 10.1242/jcs.02491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16076903-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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