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Article

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.

Genes & development - 15 Dec 2008

Gao Nan, LeLay John, Vatamaniuk Marko Z, Rieck Sebastian, Friedman Joshua R, Kaestner Klaus H

Abstract excerpt

The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox gene Pdx1 (IPF1). Pdx1 is essential for the expansion of the pancreatic primordium and the development of endocrine islets. The control of Pdx1 expression has been only partially elucidated. We demonstrate here that the winged-helix transcription factors Foxa1 and Foxa2 co-occupy multiple regulatory domains in the...

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Identifiers

PMID: 19141476
DOI: 10.1101/gad.1752608
PMCID: PMC2607077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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