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Article

The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2004

Bush Jeffrey O, Lan Yu, Jiang Rulang

Abstract excerpt

Cleft lip and palate (CL/P) is a common disfiguring birth defect with complex, poorly understood etiology. Mice carrying a spontaneous mutation, Dancer (Dc), exhibit CL/P in homozygotes and show significantly increased susceptibility to CL/P in heterozygotes [Deol, M. S. & Lane, P. W. (1966) J. Embryol. Exp. Morphol. 16, 543-558 and Trasler, D. G., Kemp, D. & Trasler, T. A. (1984) Teratology 29, 101-104],...

Topics

Animals
Chromosome Mapping
Cleft Lip
Cleft Palate
Introns
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Sequence Analysis, DNA
T-Box Domain Proteins

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Identifiers

PMID: 15118109
DOI: 10.1073/pnas.0401025101
PMCID: PMC406459

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The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene.PMID 15118109Read ↗

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