Article
Tbx22 expressions during palatal development in fetuses with glucocorticoid-/alcohol-induced C57BL/6N cleft palates.
The Journal of craniofacial surgery - 1 Sept 2009
Kim Soung Min, Lee Jong Ho, Jabaiti Samir, Lee Suk Keun, Choi Jin Young
Abstract excerpt
T-box transcription factor 22 (Tbx22) belongs to the T-box family of transcription factors and was originally found using an in silico approach to identify new genes in the human Xq12-Xq21 region. Mutations in Tbx22 have been reported in families with X-linked cleft palate and ankyloglossia, but the underlying pathogenetic mechanism remains unknown. The aim of this study was to evaluate the expression of Tbx22...
Topics
- Animals
- Cleft Palate
- DNA-Binding Proteins
- Dexamethasone
- Disease Models, Animal
- Ethanol
- Female
- Gene Expression Regulation, Developmental
- Gestational Age
- Glucocorticoids
- HSP70 Heat-Shock Proteins
