Article
The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia.
Nature genetics - 1 Oct 2001
Braybrook C, Doudney K, Marçano A C, Arnason A, Bjornsson A, Patton M A, Goodfellow P J, Moore G E, Stanier P
Abstract excerpt
Formation of the secondary palate is a complex step during craniofacial development. Disturbance of the events affecting palatogenesis results in a failure of the palate to close. As a consequence of deformity, an affected child will have problems with feeding, speech, hearing, dentition and psychological development. Cleft palate occurs frequently, affecting approximately 1 in 1,500 births; it is usually...
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