Article
Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2002
Bush Jeffrey O, Lan Yu, Maltby Kathleen M, Jiang Rulang
Abstract excerpt
Mutations in the TBX22 gene have been identified recently in patients with the X-linked cleft palate and ankyloglossia syndrome, suggesting that the TBX22 transcription factor plays an important role in palate development. However, because ankyloglossia has been reported in the majority of patients with TBX22 mutations, it has been speculated that the cleft palate phenotype is secondary to defective fetal tongue...
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