Article
Cloning and expression analysis of the chick ortholog of TBX22, the gene mutated in X-linked cleft palate and ankyloglossia.
Mechanisms of development - 1 Sept 2002
Haenig Bénédicte, Schmidt Corina, Kraus Florian, Pfordt Markus, Kispert Andreas
Abstract excerpt
T-box genes constitute a conserved gene family with important roles in many developmental processes. Several family members have been implicated in human congenital diseases. Recently, mutations in TBX22 were found to cause X-linked cleft palate (CPX and ankyloglossia), a semidominant X-linked disorder affecting formation of the secondary palate. Here, we have cloned the chick ortholog of human TBX22 and have...
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